Differential gene methylation patterns in cancerous and non‑cancerous cells
نویسندگان
چکیده
منابع مشابه
Distinguishing cancerous from noncancerous cells through analysis of electrical noise.
Since 1984, electric cell-substrate impedance sensing (ECIS) has been used to monitor cell behavior in tissue culture and has proven sensitive to cell morphological changes and cell motility. We have taken ECIS measurements on several cultures of noncancerous and cancerous human ovarian surface epithelial cells. By analyzing the noise in real and imaginary electrical impedance, we demonstrate t...
متن کاملQuantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues.
OBJECTIVES Hippostasin/kallikrein 11 (KLK11) is a member of the human kallikrein gene family, which includes prostate-specific antigen (PSA), human kallikrein 2 (hK2), and another 12 members, all localized on chromosome 19q13.4. Hippostasin has two alternative splicing isoforms, known as the brain type and prostate type. We have previously reported that the prostate-type isoform is not expresse...
متن کاملLINE-1 methylation patterns of different loci in normal and cancerous cells
This study evaluated methylation patterns of long interspersed nuclear element-1 (LINE-1) sequences from 17 loci in several cell types, including squamous cell cancer cell lines, normal oral epithelium (NOE), white blood cells and head and neck squamous cell cancers (HNSCC). Although sequences of each LINE-1 are homologous, LINE-1 methylation levels at each locus are different. Moreover, some l...
متن کاملNuclear methylation levels in normal and cancerous thyroid cells.
BACKGROUND Most cancers show abnormal DNA methylation and a positive correlation between hypomethylation and tumour progression. PATIENTS AND METHODS In our laboratory the extent of DNA methylation in individual nuclei in normal, cancer and non-cancer thyroid tissue samples was quantified according to a previously described method of computer-assisted semi-quantitative analysis. Cancer and no...
متن کاملQuantitative ratiometric discrimination between noncancerous and cancerous prostate cells based on neuropilin-1 overexpression.
A multiplexed, ratiometric method is described that can confidently distinguish between cancerous and noncancerous epithelial prostate cells in vitro. The technique is based on bright surface-enhanced resonance Raman scattering (SERRS) biotags (SBTs) infused with unique Raman reporter molecules, and carrying cell-specific peptides. Two sets of SBTs were used. One targets the neuropilin-1 (NRP-1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncology Reports
سال: 2019
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.2019.7159